The impact of male partners on reproductive success is often overlooked, but in the Male Fertility Research Program at the C.S. Mott Center for Human Growth and Development, we understand that the health of babies starts with the health of sperm prior to conception. We embrace the uniqueness of our local community and urban environment by providing an integrative “omics” approach to research- a rapidly evolving, multidisciplinary, and emerging field that encompasses genomics, epigenomics, transcriptomics, proteomics, and metabolomics. This allows us to understand the interaction of cell development with genetic, epigenetic, and environmental determinants of male fertility, with the goal of improving couples’ reproductive success. Through these efforts, we aim to deliver a personalized approach to reproductive health, with men as equal partners, that will ultimately transform the life course of children in Detroit and around the world.