MPO NEts

Publications

Find links to her publications below

1. Moreno de Lara L, Werner A, Borchers A, Carrillo-Salinas FJ, Marmol W, Parthasarathy S, Iyer V, Vogell A, Illanes D, Abadia-Molina AC, Ochsenbauer C, Wira CR, Rodriguez-Garcia M. Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues. 2023. Front. Immunol. 14:1256182. doi: 10.3389/fimmu.2023.1256182.

2. Parthasarathy S, Shen Z, Carrillo-Salinas FJ, Wira CR and Rodriguez-Garcia M. Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa. 2023. Immun Ageing. Jul 14;20(1):34.

3. Perry WA, Martino EAE, Rodriguez-Garcia M, Chow JK, Snydman DR. Sex- and age-based comparison of serum immunoglobulins following liver transplantation. Transplant Immunology. 2023 Jun;78:101826.

4. Shen Z, Patel MV, Rodriguez-Garcia M and Wira CR. Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium. 2022. Immun Ageing. Nov 12;19(1):55.

5. Perry WA, Gardiner BJ, Price LL, Rodriguez-Garcia M, Chow JK, Snydman DR. Female sex and advanced age are associated with invasive cytomegalovirus disease in solid organ transplant recipients. 2022. Transplant Infectious Disease. 2022 Oct 19;e13960

6. Francisco Carrillo-Salinas, Siddharth Parthasarathy, Laura Moreno de Lara, Anna Borchers, Christina Ochsenbauer, Alexander Panda, Marta Rodriguez-Garcia. Short-chain fatty acids impair neutrophil antiviral function in an age-dependent manner. Cells. 2022, 11(16), 2515.

7. Patel MV, Rodriguez-Garcia M, Shen Z, Wira CR. Medroxyprogesterone acetate inhibits wound closure of human endometrial epithelial cells and stromal fibroblasts in vitro. Sci Rep. 2021 Dec 1;11(1):23246.

8. Patel MV, Shen Z, Rodriguez-Garcia M, Tafe L, Usherwood E, Wira CR. Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women. Front Immunol. 2021. Apr 23;12:657326.

9. Shen Z, Rodriguez-Garcia M, Patel MV, Wira CR. Direct and Indirect Endocrine-Mediated Suppression of Human Endometrial CD8+T cell Cytotoxicity. Sci Rep. 2021 Jan 19;11(1):1773.

10. Rodriguez-Garcia M, Shen Z, Fortier JM, Wira CR. Differential Cytotoxic Function of Resident and Non-Resident CD8+ T Cells in the Human Female Reproductive Tract before and after Menopause. Front Immunol. 2020 Jun 4;11:1096.

11. Shen Z, Rodriguez-Garcia M, Patel MV, Bodwell J, Wira CR. Epithelial Cells and Fibroblasts from the Human Female Reproductive Tract Accumulate and Release TFV and TAF to Sustain Inhibition of HIV Infection of CD4+ T cells. Sci Rep. 2019 Feb 12;9(1):1864.

12. Barr F, Ochsenbauer C, Wira CR, Rodriguez-Garcia M*. Neutrophil Extracellular Traps Prevent HIV Infection in the Female Genital Tract. Mucosal Immunol. 2018 Sep;11(5):1420-1428.*Images selected for the cover.

13. Rodriguez-Garcia M, Fortier JM, Barr F, Wira CR. Aging Impacts CD103+CD8+ T Cell Presence and Induction by Dendritic Cells in the Genital Tract. Aging Cell. 2018 Jun;17(3):e12733.

14. Rodriguez-Garcia M, Fortier JM, Barr F, Wira CR. Isolation of Dendritic Cells from the Human Female Reproductive Tract for Phenotypical and Functional Studies. J Vis Exp. 2018 Mar 13;(133). doi: 10.3791/57100

15. Shen Z, Rodriguez-Garcia M, Patel MV, Bodwell J, Kashuba AD and Wira CR. Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and Intracellular TFV-DP Concentrations in CD4+ T cells from Blood and the Female Reproductive Tract. Sci Rep. 2017 Dec 18;7(1):17697.

16. Mukura LR, Hickey DK, Rodriguez-Garcia M, Fahey JV, Wira CR. Chlamydia trachomatis regulates innate immune barrier integrity and mediates cytokine and antimicrobial responses in human uterine ECC-1 epithelial cells. Am J Reprod Immunol. 2017 Dec;78(6).

17. Shen Z, Rodriguez-Garcia M, Ochsenbauer C, Wira CR. Characterization of immune cells and infection by HIV in human ovarian tissues. Am J Reprod Immunol. 2017 Jul;78(1).

18. Rodriguez-Garcia M, Patel MV, Shen Z, Bodwell J, Rossoll R, Wira CR. Tenofovir inhibits wound healing of epithelial cells and fibroblasts from the upper and lower human female reproductive tract. Sci Rep. 2017 Apr 3;8:45725

19. Rodriguez-Garcia M, Shen Z, Barr F, Boesch AW, Ackerman ME, Kappes JC, Ochsenbauer C, Wira CR. Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV. Mucosal Immunol. 2017 Mar;10(2):531-544

20. Shen Z, Rodriguez-Garcia M, Barr F, Patel MV, Wira CR. Menopausal status influences the expression of program death (PD)-1 and its ligand PD-L1 on immune cells from the human female reproductive tract. Am J Reprod Immunol. 2016 Aug;76(2):118-25.

21. Oliva H, Pacheco R, Martinez-Navio JM, Rodríguez-García M, Naranjo-Gómez M, Climent N, Prado C, Gil C, Plana M, García F, Miró JM, Franco R, Borras FE, Navaratnam N, Gatell JM, Gallart T. Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4+ T-cell activation and dendritic cell maturation. Immunol Cell Biol. 2016 Aug;94(7):689-700

22. Biswas N, Rodriguez-Garcia M, Shen Z, Crist SG, Bodwell JE, Fahey JV, Wira CR. Effects of tenofovir on cytokines and nucleotidases in HIV-1 target cells and the mucosal tissue environment in the female reproductive tract. Antimicrob Agents Chemother. 2014 Nov;58(11):6444-53.

23. Shen Z, Fahey JV, Bodwell JE, Rodriguez-Garcia M, Kashuba AD, Wira CR. Basal and Sex Hormone Regulated Tenofovir-Diphosphate Levels in Female Reproductive Tract Cells in Culture. 2014. PLos One. 2014 Jun 30;9(6):e100863.

24. Rodriguez-Garcia M, Barr FD, Crist SG, Fahey JV, Wira CR. Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract. Mucosal Immunol. 2014 Nov;58(11):6444-53

25. Biswas N, Rodriguez-Garcia M, Crist SG, Shen Z, Bodwell JE, Fahey JV, Wira CR. Effect of Tenofovir on Nucleotidases and Cytokines in HIV-1 Target Cells. PLoS One. 2014 Jun 30;9(6):e100863.

26. Boesch AW, Zhao Y, Landman AS, Rodriguez-Garcia M, Fahey JV, Charles R. Wira, Margaret E. Ackerman. A Multiplexed Assay to Detect Antimicrobial Peptides in Biological Fluids and Cell Secretions. J Immunol Methods. 2013 Nov 29;397(1-2):71-6.

27. Shen Z, Fahey JV, Bodwell JE, Rodriguez-Garcia M, Rossoll RM, Crist SG, Patel MV and Wira CR. Estradiol Regulation of Nucleotidases in Female Reproductive Tract Epithelial Cells and Fibroblasts. PLoS One. 2013 Jul 25;8(7):e69854.

28. Rodriguez-Garcia M, Biswas N, Patel MV, Barr FD, Crist SG, Ochsenbauer C, Fahey JV, Wira CR. Estradiol reduces susceptibility of CD4+ T cells and macrophages to HIV-infection. PLoS One. 2013 Apr 17;8(4):e62069.

29. Casanova V, Naval-Macabuhay I, Massanella M, Rodríguez-García M, Blanco J, Gatell JM, García F, Gallart T, Lluis C, Mallol J, Franco R, Climent N, McCormick PJ. Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals. PLoS One. 2012;7(12):e51287.

30. Escribese MM*, Rodríguez-García M*, Sperling R, Engel SM, Gallart T, Moran TM. Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen. Reprod Biol Endocrinol. 2011 Aug 23;9:118. * Equal contribution.

31. Porichis F, Kwon DS, Zupkosky J, Tighe DP, McMullen A, Brockman MA, Pavlik DF, Rodriguez-Garcia M, Pereyra F, Freeman GJ, Kavanagh DG, Kaufmann DE. Responsiveness of HIV-specific CD4 T cells to PD-1 blockade. Blood. 2011 Jul 28;118(4):965-74.

32. Rodríguez-García M, Porichis F, De Jong O, Diefenbach TM, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG. Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr;89(4):507-15

33. Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, Loubeau M, Ge Y, Garrido JL, Rodríguez-García M, Moran TM. Peripheral Blood Cytokine Profiling during Pregnancy and Post-partum Periods. Am J Reprod Immunol. 2010 Dec;64(6):411-26.

34. Rodríguez-García M, Climent N, Oliva H, Casanova V, Franco R, Leon A, Gatell JM, García F, Gallart T. Increased α-Defensins 1-3 Production by Dendritic Cells in HIV-Infected Individuals Is Associated with Slower Disease Progression. 2010. PLoS ONE 5(2): e9436.

35. Rodriguez-Garcia M, Oliva H, Climent N, Escribese M, Garcia F, Moran TM, Gatell JM, Gallart T. Impact of α-defensins1-3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effects. Clin Immunol. 2009 Jun;131(3):374-84.

36. Alvarez I, Collado J, Daura X, Colomé N, Rodríguez-García M, Gallart T et al. The rheumatoid arthritis associated allele HLA-DR10 (DRB1*1001) shares part of its repertoire with HLA-DR1 (DRB1*0101) and HLA-DR4 (DRB*0401). Arthritis Rheum 2008 Jun;58(6):1630-9.

37. Rodríguez-García M, Oliva H, Climent N, García F, Gatell JM, and Gallart T. Human Monocyte-derived Dendritic Cells Produce and Secrete Alpha-defensins1-3. J Leukoc Biol 2007 82: 1143–1146.

Review articles.

1. Rodriguez-Garcia M, Patel MV, Shen Z, Wira CR. The Impact of Aging on Innate and Adaptive Immunity in the Human Female Genital Tract. Aging Cell. 2021. May 5:e13361.

2. Rodriguez-Garcia M, Connors K, Ghosh M. HIV Pathogenesis in the Human Female Reproductive Tract. Current HIV/AIDS rep. 2021. Apr;18(2):139-156.

3. Moreno de Lara M, Parthasarathy RS, Rodriguez-Garcia M. Mucosal Immunity and HIV acquisition in women. Curr Opin Physiol. 2021 Feb;19:32-38.

4. Shacklett BL, Blanco J, Hightow-Weidman L, Mgodi N, Alcami J, Buchbinder S, Chirenje M, Dabee S, Diallo M, Dumchev K, Herrera C, Levy ME, Martin-Gayo E, Makoah NA, Mitchell KM, Mugwanya K, Reddy K, Rodríguez ML, Rodriguez-Garcia M, Shover CL, Shrivastava T, Tomaras GD, Van Diepen M, Walia M, Warren M, Manrique A, Thyagarajan B, Torri T. HIVR4P 2018: From Research to Impact. AIDS Res Hum Retroviruses. 2019 Apr 22. doi: 10.1089/AID.2019.0074.

5. Patel, M. V., Rodriguez-Garcia M, Wira, C. R. Role of Sex Hormones in Regulating Innate Immune Protection against HIV in the Human Female Reproductive Tract. Current Immunol. Rev. 2019; 15(1)

6. Wira CR, Rodriguez-Garcia M, Patel MV. The role of sex hormones in immune protection of the female reproductive tract. Nature Reviews in Immunology. 2015 Apr;15(4):217-30.

7. Wira CR, Fahey JV, Rodriguez-Garcia M, Shen Z, Patel MV. Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens. Am J Reprod Immunol. 2014 Aug;72(2):236-58.

8. Wira CR, Rodriguez-Garcia M, Shen Z, Patel M, Fahey JV. The role of sex hormones and the tissue environment in immune protection against HIV in the female reproductive tract. Am J Reprod Immunol. 2014 Aug;72(2):171-81.

9. Ghosh M, Rodriguez-Garcia M, Wira CR. The Immune System in Menopause: Pros and Cons of Hormone Therapy. J Steroid Biochem Mol Biol. 2014 Jul;142:171-5.

10. #Rodriguez-Garcia M, Patel MV, Wira CR. Innate and Adaptive Anti-HIV Immune Responses in the Female Reproductive Tract. J Reprod Immunol. 2013 Mar;97(1):74-84. # Highly Cited Research Award, November 2016

11. Ghosh M, Rodriguez-Garcia M*, Wira CR. Immunobiology of Genital Tract Trauma: Endocrine Regulation of HIV Acquisition in Women Following Sexual Assault or Genital Tract Mutilation. Am J Reprod Immunol. 2013 Feb;69 Suppl 1:51-60. *Equal contribution.

12. Mas V, González C, Rodriguez M, Amézaga N, Calvo J, Gaya A. Cytokines and Chemokines in physiopathological processes. IX Monographic Symposium of the Spanish Society for Immunology. Immunología. January 2005; 24(1):55-58

Editorials and commentary articles

1. Rodriguez-Garcia M, Alcaide P. Vascular inflammation and hyperlipidemia: the neutrophil within. JACC: Basic to Translational Science. Editorial. 2021. Jun 28;6(6):524-526.

2. Rodriguez-Garcia M. How HIV exploits T cells in the endometrium. eLife. 2020;9:e58169

Book chapters

1. Wira CR, Rodriguez-Garcia M, Shen Z, Patel MV. Endocrine Control of Mucosal Immunity in the Human Female Reproductive Tract: Bridging Implantation with Pathogen Protection. In: Reproductive Immunology: Basic Concepts. Gil Mor. Elsevier. 2021. In press.

2. Rodriguez-Garcia M, Patel MV, Shen Z, Fahey JV, Biswas N, Mestecky J, Wira CR. Mucosal Immunity in the Human Female Reproductive Tract. In: Mucosal Immunology. Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, Mayer L. Academic Press. 4th Edition, 2015.

3. Wira CR, Rodriguez-Garcia M, Patel MV, Biswas N, Fahey JV. Endocrine Regulation of the Mucosal Immune System in the Female Reproductive Tract. In: Mucosal Immunology. Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, Mayer L. Academic Press. 4th Edition, 2015.

4. Wira CR, Patel MV, Ghosh M, Shen Z and Rodríguez-García M. Innate and Adaptive Immunity in the Human Female Reproductive Tract: Bridging the Menstrual Cycle with Pregnancy. In: Immunology of Pregnancy. Chaouat G, Sandra O, Ledee N. Bentham eBooks, 2013. 3-58.

5. Wira CR, Rodriguez-Garcia M, Patel MV. Mucosal Immunity in the Human Reproductive Tract: Balancing Reproductive Potential with Protection against Sexually Transmitted Pathogens. In: Sexually Transmitted Diseases: Vaccines, Prevention and control. Stanberry LR and Rosenthal SL. Academic Press. Second Edition 2013. 72-110.

6. Rodriguez-Garcia M, Lozano Soto F, Serrano Hernandez A. Métodos en inmunidad celular, en: Técnicas de investigación básica en reumatología. F.J. Blanco, J.D. Cañete, J.L. Pablos. Editorial Médica Panamericana, 2007. 50-73.