Congratulations to Drs. Puscheck, Rappolee, and Ruden for receiving new grants

The department would like to congratulate Daniel Rappolee, Ph.D. (Co-PI), Mohammed Abdulhasan, Ph.D. (Co-PI) and Elizabeth Puscheck, M.D., M.S., M.B.A. (AOR and Consultant) on receiving an NIH R41 Grant entitled “Stress forces huESC differentiation; confirmation as an accurate DevTox HTS.” This grant award is for $225,000. The Michigan Emerging Technology Grant Fund is also awarding Dr. Rappolee a grant to extend the R41 for $25,000. The focus of this research is to translate patented high throughput screening assays which currently use stress-sensing fluorescent reporters in mouse embryonic stem cells (muESC) to human (hu)ESC. This assay system predicts the effects of different stressors, toxicants or exposures (i.e. new drugs, established medications, environmental toxicants, stress hormones, diet supplements, infections, etc.) on early development of a baby (miscarriage, birth defects, abnormally small babies), on the fetal origin of adult disease and on potentially impacting the next generation.

Similar current work is sponsored by P30 5P30ES020957-07 Center for Urban Responses to Environmental Stressors (P.I. Melissa Runge-Morris) as a pilot grant for Co-I’s Daniel Rappolee, Ph.D. and Douglas Ruden, Ph.D. to study whether stressors (Phthalates, PFOA, cortisol) result in muESC growth, transcriptomic and epigenetic changes that may impact the genetic lineage of future generations.

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