Recanati Lab

Maurice-Andre Recanati, MD-MS, FACOG

Graduated from the French educational system with a Baccalaureat Scientifique in physics and mathematics. Dr. Recanati graduated at the top of the class from Rensselaer Polytechnic Institute with a bachelor's in Physics and holds a Masters of Science in Mechanical Engineering from the Massachusetts Institute of Technology. After graduating from the Duke University School of Medicine and completing residency at the University of California at San Francisco in Obstetrics & Gynecology, Dr. Recanati joined the faculty of Wayne State University and was awarded an NIH Women's Reproductive Health Research Scholarship (K-12 award).

As a clinician-scientist, Dr. Recanati teaches residents and treats patients in the clinic, on labor and delivery and in the operating rooms at the Detroit Medical Center.


About

The Recanati lab primarily conducts translational research in the field of mitochondrial physiology as it relates to Women's health. We employ a diverse group of scientists, primarily at the post-doctoral level, and perform high impact research in the field of obstetrics and gynecology.

Obstetric projects active in the group currently center on the placenta as an organ and understanding its role in promoting fetal lung maturity at the molecular level. Our lab has discovered a protein, LPCAT1, which can be used as a non-invasive marker of fetal lung maturity. This protein, in turn, is upregulated by hypoxia as sensed by a mitochondrial protein.

Gynecologically, our lab is exploring methods to reduce (and possibly eliminate) postoperative adhesion formation. These adhesions can cause problems such as pain, infertility, bowel obstruction, the need to re-operate and complications at all future surgeries. We have discovered that hypoxia and dysregulation of mitochondrial function causes fibroblasts to irreversibly convert to adhesion phenotype. Thus, we are actively pursuing methods to reduce adhesions though a mitochondrial based approach.

The Recanati lab is committed to the improvement of medicine through innovation and technology. We have leveraged the resources of the Detroit Medical Center, the Wayne State School of Medicine and the Wayne State School of Engineering to design medical products with clinical applications. Some such applications include a laparoscopic scope washer, a non-invasive tenaculum and an advanced fetal heart rate monitor.


Research and Publications

Presentations

Grants

Lab Members