Tumor Immunology and Therapies

Research Overview

The Tumor Immunology and Therapies group in the C.S. Mott Center for Human Growth and Development is composed of basic science researchers and clinician scientist in the field of ovarian cancer research. As majority of ovarian cancer patients succumb to the disease during the recurrent stage, the group's objective is anchored upon the better understanding and management of recurrent ovarian cancer. Collectively, the group focuses on: drug discovery, development of novel immunotherapies, drug delivery platforms, markers for early detection, and development of relevant in vitro and in vivo models.

Faculty

Ayesha Alvero, MD, MSc

Gil Mor, MD, PhD

Radhika Gogoi, MD, PhD

Roslyn Tedja, PhD

  • Members

    Current Members        

     

         

    Hussein Chehade

    PhD Student  

     

     

     

     

               

    Alexandra Fox     

    Research Assistant

     

     

     

     

     

     

  • 2020 Publications

    Alvero AB, Hanlon D, Pitruzzello M, Filler R, Robinson E, Sobolev O, Tedja R, Ventura A, Bosenberg M, Edelson R, Mor G.  Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer. Oncoimmunology, 2020.

    Li J, Alvero AB, Nuti S, Tedja R, Roberts CM, Pitruzzello M, Li Y, Xiao Q, Zhang S, Gan Y, Wu X, Mor G, Yin G. CBX7 binds the E-box to inhibit TWIST-1 function and inhibit tumorigenicity and metastatic potential. Oncogene, 2020.

    Dasari, VR, Carey DJ, Gogoi R. Synergistic enhancement of efficacy of platinum drugs with verteporfin in ovarian cancer cells. BMC Cancer, 2020.